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- ArticleSaborowski F, Lang D, Scholand C, Albers C.Recent Adv Stud Cardiac Struct Metab. 1975;5:465-71.The effect of temperature on hydrogen ions and buffer capacity in extracellular fluid differs from the effects in intracellular fluid. In our experiments cardiac hypertrophy was achieved by increasing the mechanical work load. It could be demonstrated that there is a certain correlation between buffering of hydrogen ions and mechanical activity of heart muscle.